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Extra info for Deutsche Gesellschaft für Pharmakologie und Toxikologie: Abstracts of the Autumn Meeting 10–14 September 1991, Berlin

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Over the past few years we have determined complete or partial amino acid sequence for 5 different POE isozymes and used this information to isolate partial eDNA clones for seven representatives of three POE families. In addition, other laboratories have described partial or complete eDNA clones for members of the, the low km, cAMP-specific and photoreceptor cGMP-specific PDEs. Finally, very recently Manganiello and colleagues have presented predicted sequence data for one member of the cGMP-inhibited POE family.

As an example the prospects of the powerful CSFs will be discussed in the presentation of K. Welte. The interaction of xenobiotics with target organs such as liver, generally results in loss of function, if these xenobiotics reach toxic concentrations. With the immune system - and thus immunotoxicology - again reactions can be ambiguous. Like with other organs, cells can be destroyed, resulting in immunodeficiency. For some environmental toxins, the developing immune system appears to be exquisitely sensitive.

Firstly it comprises all pharmacological maneuvers to interfere with the function of the immune system. Among these immunosuppressive drugs have gained great importance in the treatment of autoimmune diseases or chronic inflammatory disorders, as well as in allowing succesful transplantation of allogeneic organs or cells. Until recently, immunosuppressive drugs were mostly cytotoxic such as cyclophosphamid. Because of the large diversity of lymphocytes ( 106-108) competitive antigen receptor antagonists are not feasible.

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