By Ciba Foundation Symposium 26
Chapter 1 Chairman's creation (pages 1–3): Alan S. Curry
Chapter 2 The Clinician's specifications from the Laboratory within the remedy of the Acutely Poisoned sufferer (pages 5–15): R. W. Newton
Chapter three The function of the Laboratory within the remedy of Narcotic Poisoning (pages 17–28): Vincent P. Dole
Chapter four Formation of Reactive Metabolites as a reason for Drug Toxicity (pages 29–55): James R. Gillette
Chapter five Separation and Detection of risky Metabolites of Amphetamines, Analgesics and Phenothiazines (pages 57–82): A. H. Beckett
Chapter 6 evaluate of Chromatographic and Spectroscopic systems (pages 83–103): A. C. Moffat
Chapter 7 Use of gasoline Chromatography?Mass Spectrometry in Toxicological research (pages 105–124): Bo Holmstedt and Jan?Erik Lindgren
Chapter eight decision of hashish parts in Blood (pages 125–137): Stig Agurell
Chapter nine Drug Assay through Radioactive Reagents (pages 139–154): W. Riess
Chapter 10 An On?Line Liquid Chromatograph?Mass Spectrometer method (pages 155–169): R. P. W. Scott, C. G. Scott, M. Munroe and J. Hess
Chapter eleven Luminescence equipment in Drug research (pages 171–192): J. W. Bridges
Chapter 12 Immunoassay of substances (pages 193–200): Irving Sunshine
Chapter thirteen Immunological tools for Detecting medicines: their program within the Detection of Digitoxin, Digoxin and Morphine (pages 201–217): Charles W. Parker
Chapter 14 Drug research within the Overdosed sufferer (pages 219–238): B. Widdop
Chapter 15 The Morbid Anatomist's position in Drug Detection (pages 239–251): D. J. Gee
Chapter sixteen Drug?Induced Iatrogenic illness: the likelihood of its Detection (pages 253–268): Henry Leach
Chapter 17 boundaries of Haemodialysis and compelled Diuresis (pages 269–289): L. F. Prescott
Chapter 18 The Poisoned sufferer: The Clinician and the Laboratory (pages 291–314): Roy Goulding
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Additional info for Ciba Foundation Symposium 26 - The Poisoned Patient: The Role of the Laboratory
21, 169-172 G R E E F. , STRIPP, B. & GILLETTE, J. R. (1969) Bwchem. Pharmacol. 18,1531-1533 JAGENBURG, 0. R. & TOCZKO, K. (1964) Biochem. J. , MITCHELL, J. , ZMAGLIONE, N. & GILLETTE, J. R. (1972) V In?. Congr. Pharmol. Abs. Vol. Papers 117, Karger, Basel JOLLOW, D. , MITCHELL, J. , P m , W. , DAVIS,D. ,G I L ~J. R. , & BRODIE, B. B. (1973~)J. Pharmawl. Exp. Ther. 195-202 JOLLOW,D. , THORGWS~ON, S. , POTIER,W. , MITCHELL,J. , GILLFITE,J. R. & BRODIE, B. B. (19736) Fed. Proc. 32,305 JOLLOW, D. , M~~CHELL, J.
Indeed, inducers and inhibitors of drug-metabolizing enzymes would be expected to exert their greatest effect on A by changing the activity of an enzyme that catalyses the formation of the reactive metabolite along a relatively minor pathway without affecting the rate of formation of metabolites along the major pathways of elimination. Hence inducers and inhibitors may greatly affect A without markedly affecting the biological halflife of the parent compound, whereas inducers and inhibitors that greatly change the biological half-life of the parent compound may not always cause marked changes in A.
74, 551 HSIA,J. C. , H. (1969) Spin-labelling as a general method in studying antibody active site. Arch. Biochem. Biophys. 129, 296-307 The Poisoned Patient: the role of the laboratoo Ciba Foundatjon Copyright 0 1974 Ciba Foundation Formation of reactive metabolites as a cause of drug toxicity JAMES R. GILLE'TTE Laboratory of Chemical Pluamacology. National Heart and Lung Institute, National Institutes of Health, Bethesh, Maryland Abstruct The principles of pharmacokineticsof reactive metabolitesare used to explain how various inducers and inhibitors of drug-metabolizingenzymes and various doses can affect the covalent binding of reactive metabolites of bromobenzene, acetaminophen(paracetamol) and furosemide to tissue macromolecules such as protein.