Download Ciba Foundation Symposium 190 - Somatostatin and its by CIBA Foundation Symposium PDF

By CIBA Foundation Symposium

This e-book describes a various research of the 5 somatostatin receptors; somatostatin gene rules; promatostatin processing; mechanisms of sign transduction; and the layout and use of somatostatin analogues, together with their attainable scientific implications. The publication will offer a accomplished precis of the mobile and molecular biology of somatostatin and its lately remoted receptors. The e-book will evaluate the layout and use of particular somatostatin analogues either biochemically to represent the explicit services of somatostatin and clinically within the remedy of varied tumors.

Content:

Show description

Read or Download Ciba Foundation Symposium 190 - Somatostatin and its Receptors PDF

Similar physiology books

Stress physiology and forest productivity: Proceedings of the Physiology Working Group Technical Session. Society of American Foresters National Convention, Fort Collins, Colorado, USA, July 28–31, 1985

Protecting or expanding stand productiveness is the fear of woodland land managers all over the world. therefore, there's expanding curiosity in knowing the influence of environmental tension on productiveness and the advance of administration techniques that ameliorate or lessen the deleterious results.

Marshall’s Physiology of Reproduction: Volume 3 Pregnancy and Lactation

The main entire assessment to be had this day, Marshall's body structure of copy is the vintage reference resource for lecturers and researchers of animal copy. across the world acknowledged leaders of their respective fields supply an analytical synopsis of the realm, overview present learn and description their philosophical method of the topic.

Clinical Neurophysiology of Infancy, Childhood, and Adolescence

This specific reference is exclusive in its particular devotion to the scientific neurophysiology of youngsters. Written via a stellar team of well-known experts, it blends classical electrophysiological options corresponding to EEG, EMG, and nerve conduction stories with modern-day such a lot state of the art equipment, together with magnetic stimulation and magnetoencephalography.

The Scientific Bases of Human Anatomy

As clinical colleges fight to slot ever extra fabric right into a mounted period of time, scholars have to strategy the learn of anatomy via a succinct, integrative evaluation. instead of environment forth an overpowering checklist of evidence to be memorized, this e-book engages readers with a desirable account of the connections among human anatomy and a big selection of medical disciplines, weaving within the most recent advances in developmental and evolutionary biology, comparative morphology, and organic engineering.

Extra resources for Ciba Foundation Symposium 190 - Somatostatin and its Receptors

Example text

Cleavage at a dibasic Arg-Lys site produces somatostatin-14 and a 8 kDa peptide whereas cleavage at a monobasic Arg site releases somatostatin-28 and a 7 kDa form. In addition, there is a second monobasic Lys processing site at the N-terminal segment of the precursor which generates the decapeptide antrin, or prosomatostatin, a molecule without any known biological activity. In lower vertebrates such as fish, there are two distinct somatostatin genes expressed in separate subpopulations of cells which encode for separate somatostatin-14 and somatostatin-28 related products (reviewed in Patel 1992).

3B). These results indicate that PCl is capable of dibasic processing of prosomatostatin and is a candidate somatostatin-14 convertase. Furthermore, because COS-7 cells are constitutively secreting, these findings suggest that proteolytic 35 Prosomatostatin processing 100, - h 0 80 60 I= 0 40 $ 20 v 0 PSS PSS+PCl Somatostatin-28 unprocessed Prosomatostatin Cell Extracts 100, ! 20 0 FIG. 3B. Comparison of per cent processed somatostatin-14 and somatostatin-28 with unprocessed prosomatostatin (PSS) in COS-7 cells transfected with prosomatostatin alone, co-transfected with prosomatostatin and mouse PCI or co-transfected with prosomatostatin and mouse PC2.

3B. Comparison of per cent processed somatostatin-14 and somatostatin-28 with unprocessed prosomatostatin (PSS) in COS-7 cells transfected with prosomatostatin alone, co-transfected with prosomatostatin and mouse PCI or co-transfected with prosomatostatin and mouse PC2. SS-14L1, somatostatin-I4-like immunoreactivity. Mean data +SE (n= 3). O5 compared to prosomatostatin control. Coexpression of PCI with prosomatostatin results in a significant increase in the per cent of somatostatin-14 processed in cell extracts and secretion media.

Download PDF sample

Rated 4.58 of 5 – based on 47 votes