By CIBA Foundation Symposium
This e-book describes a various research of the 5 somatostatin receptors; somatostatin gene rules; promatostatin processing; mechanisms of sign transduction; and the layout and use of somatostatin analogues, together with their attainable scientific implications. The publication will offer a accomplished precis of the mobile and molecular biology of somatostatin and its lately remoted receptors. The e-book will evaluate the layout and use of particular somatostatin analogues either biochemically to represent the explicit services of somatostatin and clinically within the remedy of varied tumors.
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Extra resources for Ciba Foundation Symposium 190 - Somatostatin and its Receptors
Cleavage at a dibasic Arg-Lys site produces somatostatin-14 and a 8 kDa peptide whereas cleavage at a monobasic Arg site releases somatostatin-28 and a 7 kDa form. In addition, there is a second monobasic Lys processing site at the N-terminal segment of the precursor which generates the decapeptide antrin, or prosomatostatin, a molecule without any known biological activity. In lower vertebrates such as fish, there are two distinct somatostatin genes expressed in separate subpopulations of cells which encode for separate somatostatin-14 and somatostatin-28 related products (reviewed in Patel 1992).
3B). These results indicate that PCl is capable of dibasic processing of prosomatostatin and is a candidate somatostatin-14 convertase. Furthermore, because COS-7 cells are constitutively secreting, these findings suggest that proteolytic 35 Prosomatostatin processing 100, - h 0 80 60 I= 0 40 $ 20 v 0 PSS PSS+PCl Somatostatin-28 unprocessed Prosomatostatin Cell Extracts 100, ! 20 0 FIG. 3B. Comparison of per cent processed somatostatin-14 and somatostatin-28 with unprocessed prosomatostatin (PSS) in COS-7 cells transfected with prosomatostatin alone, co-transfected with prosomatostatin and mouse PCI or co-transfected with prosomatostatin and mouse PC2.
3B. Comparison of per cent processed somatostatin-14 and somatostatin-28 with unprocessed prosomatostatin (PSS) in COS-7 cells transfected with prosomatostatin alone, co-transfected with prosomatostatin and mouse PCI or co-transfected with prosomatostatin and mouse PC2. SS-14L1, somatostatin-I4-like immunoreactivity. Mean data +SE (n= 3). O5 compared to prosomatostatin control. Coexpression of PCI with prosomatostatin results in a significant increase in the per cent of somatostatin-14 processed in cell extracts and secretion media.