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By R. J. C. Harris

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Bacillus

The genus Bacillw; has a protracted historical past of significance, either from an monetary standpoint and as a resource of experimental microorganisms. This quantity seriously experiences elements of id, molecular biology, and progress which are of impor­ tance for the present and expected destiny exploitation of participants of this team.

Extra resources for Biological Organization At the Cellular and Supercellular Level. A Symposium Held at Varenna, 24–27 September, 1962, under the Auspices of UNESCO

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18, 46. STADTMAN, E . R . , COHEN, G . N . , L E B R A S , G , , ROBICHON-SZULMAJSTER, H , de (1961), Selective feedback inhibition and repression of two aspartokinases in the metabolism of ^ . coli. Cold Spr. Harb. Symp. quant. Biol. 26, 319, SussMAN, R , , and JACOB, F . R. Acad. , Paris, 254, 1517. TOMKINS, G . M . , and YIELDING, K , L , (1961), Regulation of the enzymatic activity of glutamic dehydrogenase mediated by changes in its structure. Cold Spr. Harb. Symp. quant. Biol. 26, 331, TRAUT, R , R .

L O V I N Y , T . , and COHEN, G . (1962). Retroinhibition et re­ pression de l'homosérine déshydrogénase d'^. coli. Biochim. biophys. Acta. ) R I L E Y , M . , P A R D E E , A. B . , JACOB, F . , and MONOD, J . (1960). On the expression of a structural gene. J. mol. Biol. 2, 216. SMITH, S . M . , and STOCKER, B . A . D . (1962). Colicinogeny and recombination. Brit. med. Bull. 18, 46. STADTMAN, E . R . , COHEN, G . N . , L E B R A S , G , , ROBICHON-SZULMAJSTER, H , de (1961), Selective feedback inhibition and repression of two aspartokinases in the metabolism of ^ .

This invariance is, however, due to the operation of a regulation mechanism in­ herent in the coupled sequence of the open system. Changes in the catalytic activity at this step are accompanied by appropriate changes in the steady state precursor concentrations. As can be seen from equations (1) and (2) the rate constant (and hence the catalytic activity due to enzyme E^) enter the values for these precursors. In particular, they are inversely related to each other which means that a lower value for E^ results in a higher value for Β and Ä, The pihng up of these precursors compensates for the lowered catalysis and vice versa.

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