By Robert B. Stewart, Larry A. Grupp (auth.), Alan A. Boulton, Glen B. Baker, Peter H. Wu (eds.)
to the Animal versions Volumes This quantity describes animal types of drug habit. due to expanding public main issue over the moral therapy of animals in learn, we felt it incumbent upon us to incorporate this common preface as a way to point out why we predict extra learn utilizing animals is critical. Animals should still purely be used whilst appropriate possible choices aren't to be had, and people can basically be experimented upon in critically proscribed conditions. substitute tactics utilizing mobile or tissue tradition are insufficient in any versions requiring tests of behavioral switch or of complicated in vivo p- cesses. in spite of the fact that, whilst the misery, soreness, or ache to the animals outweighs the expected profits for human welfare, the learn isn't really moral and shouldn't be performed. it really is principal that every person researcher study his/ her personal examine from a severe ethical point of view sooner than eng- ing in it, and think about the animals’ welfare in addition to the predicted earnings. moreover, as soon as a call to p- ceed with study is made, it's the researcher’s accountability to make sure that the animals’ welfare is of top quandary by way of acceptable housing, feeding, and greatest aid of any uncomfortable or distressing results of the experimental conditions.
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Additional resources for Animal Models of Drug Addiction
1984) Prediction of abuse liability of drugs using IV self-administration by rats. Psychophurmucology 82,&13. Cullen J. , Croes R. , and Gillis R. D. (1973) Alcohol selection by rats after experience with a sapid alcohol-sucrose solution. Q 1. Stud. Alcohol 34,769-773. Dahl L. , and Tassinari L. (1962) Effects of chronic salt ingestion. J. Exp. Med. 115,1173-1190. Deitrich R. A. and Melchior C. L. (1985) A critical assessment of animal models for testing new drugs for altering ethanol intake, in Research Advances in New Psychopharmacological Treatments for Alcoholism , Naranjo C.
H. Wu 29 Q1992 The Humana Press Inc. 30 Kiianmaa, HyytiZi, and Sinclair for studies on ethanol-related health problems. Rodents and primates have been the most widely used animals in alcohol research, but probably all species are susceptible to alcohol intoxication, acquire tolerance to alcohol, and exhibit withdrawal reactions after the terminationof alcohol administration. , 1980). Thus, useful animal models of ethanol abuse are available. Although most laboratory animals voluntarily consume ethanol (Fuller, 1985), the amount of alcohol selected varies among species, among strains within a species, and among individuals within a strain.
The two strains are first crossed to produce an F, generation, and an F, generation is then produced by randomly intercrossing individuals of the F, generation. Separate inbred strains are then started by brother-sister mating from the F, generation. The resulting inbred strains should represent a gradient of the extreme responses of the parental strains. , 1990). In these studies, only small correlations were found between the effects of high doses of ethanol and the effects of low doses, suggesting an independence of the underlying inherited mechanisms.